cenobamate will reduce the extent or impact of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Improve dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.The fentanyl skin patch is just useful for opioid-tolerant sufferers. A client is opioid-tolerant if oral opioi